Hydroxyprogesterone caproate is a progestin that is used to prevent preterm delivery in pregnant women with a history of the condition, as well as to treat gynecological disorders.
Note
This medication is only given to pregnant women who are pregnant with a single baby and who have a history of preterm delivery in the past.
The article has sections on uses, dosages, contraindications, and indications.
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What Is Gravibinan Injection (250/5mg) 2ml?
Hydroxyprogesterone caproate injection is a synthetic progestin hormone. It is used in pregnant women to reduce the risk of premature birth (preterm birth or birth before 37 weeks of gestation). It is marketed and sold by Bayer Pakistan (Pvt) Limited in Pakistan under the brand name garvibinan injection (250/5mg) 2ml.
Drug Class
Progestin or Hormone replacement therapy
Mechanism Of Action
Hydroxyprogesterone is a powerful steroid ester that has long-lasting effects. It can change proliferative endothelium into secretory endothelium, stimulate the development of mammary gland ducts, and prevent the production and/or release of gonadotropic hormone. Estradiol valerate injection is used to substitute the estrogen hormones that are lost during menopause. This replacement can relieve menopausal symptoms such as hot flashes and vaginal dryness.
Ingredients Of Gravibinan Injection (250/5mg) 2ml
Hydroxyprogesterone Caproate...........................250mg
Estradiol Valerate....................5mg
Gravibinan Injection (250/5mg) 2ml Indications or Uses.
This injection is for pregnant women. It is used to help reduce the chances of giving birth too early (preterm delivery or giving birth before 37 weeks of pregnancy).
- Treatment of Amenorrhea (absence of menstruation)
- Treatment of advanced uterine cancer.
- Treatment of abnormal bleeding caused by hormonal imbalances.
- This medicine is also used to test for estrogen production.
Contraindications Of Gravibinan Injection (250/5mg) 2ml
The following are the contraindications to the Gravibinan Injection (250/5mg) 2ml
- Active Breast cancer or currently on treatment
- Lactation
- Abnormal or unusual vaginal bleeding
- Severe headache or Migraine
- High Blood Pressure
- Blood clots or Thromboembolic disorders (deep vein thrombosis pulmonary embolism) or stroke.
- Heart problems such as Ischemic heart disease
- Kidney problems leading to generalized body swelling or edema
- Liver disease such as Active hepatitis malignant liver tumors
- Preeclampsia (high blood pressure during pregnancy and too much protein in urine)
- Major surgery with prolonged immobilization can lead to stroke or deep vein thrombosis
Dosage and Administration
Administration
This medication is administered by injection into one of your muscles, typically in the hip region (specifically the upper outer area of the buttocks). Alternatively, it can be injected under the skin on the back of your upper arm. This medication is administered once a week, with a gap of 7 days between each dose.
Dosage
Treatment should be started or medication should be given between 16 weeks and 0 days of pregnancy, and 20 weeks and 6 days of pregnancy and include
Intramuscularly (IM)
250 mg IM once every 7 days in the upper outer quadrant of the buttocks region or gluteus maximus muscle.
Subcutaneously
275 mg subcutaneously once every 7 days in the back of the upper arm either left or right.
Kindly follow your Physician guidelines for dosage of the medicine.
Pregnancy & Breastfeeding
Pregnancy
The injection can be administered in pregnancy to avoid preterm birth. Use it exactly as advised by your doctor.
Breastfeeding
If you are breastfeeding, don't use the injection.
Side Effects Of Gravibinan Injection (250/5mg) 2ml
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Most Common
- Pain swelling & Itching at the injection site
Less Common
- Hypersensitivity or Allergic reactions
- Abdominal cramps
- Breast tenderness
- Fatigue
- Hives
- Dry mouth
- Anxiety
- Chest pain
- Cough
- Dizziness or lightheadedness
- Fast heartbeat
Interactions
Ask your doctor about any potential drug interactions, and discuss all medications you are taking currently.
Special Precautions & Storage
Special Precautions
Progestins can decrease glucose tolerance, so diabetic patients should monitor their blood glucose levels.
This medication should only be administered under the direct supervision of a doctor.
Storage
Store the medicine at room temperature, away from direct sunlight, excessive heat, and moisture. Remember to keep it out of reach of children and animals, and do not use it after the expiration date.
Price
Price Reference: Servaid Pharmacy
Other Related Medicines
FAQs
Q1. What are Gravibinan Injection (250/5mg) 2ml uses in pregnancy in Urdu?
Gravibinan Injection (250/5mg) 2ml
ایک مرکب دوا ہے جو کیمیکل Hydroxyprogesterone Caproate اور Estradiol Valerate کو ملا کر بنائی گئی ہے
Estradiol Valerate ایسٹروجن ہارمون کا مصنوعی مرکب ہے۔
یہ دوا ان خواتین میں استعمال کی جاتی ہے جن کےیہاں پہلے قبل از وقت بچے کی پیدائش ہوچکی ہو۔
یہ دوا حاملہ خواتین میں قبل از وقت بچے کی پیدائش کے خطرے کو کم کرتی ہے.
Q2. What is the success rate of gravibinan injection?
Ans. Despite the use of Gravibinon injection, 11.8% of abortions occurred before the 16th week of pregnancy while 7.8% had late abortions. The success rate is approximately 20%
Q3. Is Gravibinan use in pregnancy?
Ans. Yes, Gravibinan injection is only given to pregnant women who are pregnant with a single baby and who have a history of preterm delivery in the past.
Hydroxyprogesterone caproate is a progestin present in Gravibinan injection used to prevent preterm delivery in pregnant women.
Q4. What is Gravibinan injection formula?
Ans. Gravibinan injection contains Hydroxyprogesterone Caproate and Estradiol Valerate a synthetic progestin hormone.
References
National Library of Medicine - Treatment of high risk pregnancy with gravibinon | [Internet]: pubmed.ncbi.nlm.nih.gov [Last accessed: March 08, 2024].
Hydroxyprogesterone injection Uses, Side Effects & Warnings | Drugs.com [Internet] www.Drugs.com [Last accessed: March 08, 2024].
Gravibinan 1ml Injection Uses, Side effects & Price in Pakistan | emeds.pk [Internet] www.emeds.pk [Last accessed: March 08, 2024].
Disclaimer
All information on the product's uses, dosage, side effects, formula, ingredients, indications, contraindications, drug interactions, warnings and precautions, and whether it is safe to use during pregnancy and breastfeeding is based solely on material found on the internet.And it is only provided here for general education and information purposes only.
We can not guarantee the accuracy of any of the information we published on this website. All of the information material we published is based only on FDA-approved literature and is not intended to replace expert medical advice.Always seek an expert medical advice from a health care provider before start using this medicine.
Dr. Kubra Khan
She is a skilled physician and a passionate blogger who finished her medical degree in 2017 (MBBS). She possesses the necessary clinical skills and aims to share her expertise through her writing, guiding readers on the safe and effective use of medications to minimize potential side effects.